Soluble Guanylate Cyclase: A new therapeutic target for pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension

Nitric oxide (NO) activates soluble guanylate cyclase (sGC) by binding its prosthetic heme group, thereby catalyzing cyclic guanosine monophosphate (cGMP) synthesis. cGMP causes vasodilation and may inhibit smooth muscle cell proliferation and platelet aggregation. The NO-sGC-cGMP pathway is disorde...

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Bibliographic Details
Published in:Clin Pharmacol Ther
Main Authors: Das Gupta, Asish, Bowman, Lindsay, D’Arsigny, Christine L., Archer, Stephen L.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4325399/
https://ncbi.nlm.nih.gov/pubmed/25670386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.10
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