High-Affinity Accumulation of a Maytansinoid in Cells via Weak Tubulin Interaction

The microtubule-targeting maytansinoids accumulate in cells and induce mitotic arrest at 250- to 1000-fold lower concentrations than those required for their association with tubulin or microtubules. To identify the mechanisms of this intracellular accumulation and exceptional cytotoxicity of maytan...

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Udgivet i:PLoS One
Main Authors: Goldmacher, Victor S., Audette, Charlene A., Guan, Yinghua, Sidhom, Eriene-Heidi, Shah, Jagesh V., Whiteman, Kathleen R., Kovtun, Yelena V.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324968/
https://ncbi.nlm.nih.gov/pubmed/25671541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117523
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