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A Fatal Combination: A Thymidylate Synthase Inhibitor with DNA Damaging Activity

2′-deoxy-5-ethynyluridine (EdU) has been previously shown to be a cell poison whose toxicity depends on the particular cell line. The reason is not known. Our data indicates that different efficiency of EdU incorporation plays an important role. The EdU-mediated toxicity was elevated by the inhibiti...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: Ligasová, Anna, Strunin, Dmytro, Friedecký, David, Adam, Tomáš, Koberna, Karel
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2015
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324964/
https://ncbi.nlm.nih.gov/pubmed/25671308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117459
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