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A Fatal Combination: A Thymidylate Synthase Inhibitor with DNA Damaging Activity
2′-deoxy-5-ethynyluridine (EdU) has been previously shown to be a cell poison whose toxicity depends on the particular cell line. The reason is not known. Our data indicates that different efficiency of EdU incorporation plays an important role. The EdU-mediated toxicity was elevated by the inhibiti...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4324964/ https://ncbi.nlm.nih.gov/pubmed/25671308 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117459 |
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