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Structure of a soluble super-active insulin is revealed by the nature of the complex between cyanogen-bromide-activated sepharose and amines.

Insulin-like material with elevated insulin specific acitivity is released from insulin-Sepharose in the presence of bovine-serum albumin. The mechanism of release and the chemical nature of this insulin-like material are revealed by the finding that amine-Sepharose is O-Sepharose-N-substituted isou...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wilchek, M, Oka, T, Topper, Y J
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1975
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC432464/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1055365/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.72.3.1055
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