Malaria Induces Anemia through CD8(+) T Cell-Dependent Parasite Clearance and Erythrocyte Removal in the Spleen

Severe malarial anemia (SMA) in semi-immune individuals eliminates both infected and uninfected erythrocytes and is a frequent fatal complication. It is proportional not to circulating parasitemia but total parasite mass (sequestered) in the organs. Thus, immune responses that clear parasites in org...

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Veröffentlicht in:mBio
Hauptverfasser: Safeukui, Innocent, Gomez, Noé D., Adelani, Aanuoluwa A., Burte, Florence, Afolabi, Nathaniel K., Akondy, Rama, Velazquez, Peter, Holder, Anthony, Tewari, Rita, Buffet, Pierre, Brown, Biobele J., Shokunbi, Wuraola A., Olaleye, David, Sodeinde, Olugbemiro, Kazura, James, Ahmed, Rafi, Mohandas, Narla, Fernandez-Reyes, Delmiro, Haldar, Kasturi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Microbiology 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324318/
https://ncbi.nlm.nih.gov/pubmed/25604792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02493-14
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