Malaria Induces Anemia through CD8(+) T Cell-Dependent Parasite Clearance and Erythrocyte Removal in the Spleen

Severe malarial anemia (SMA) in semi-immune individuals eliminates both infected and uninfected erythrocytes and is a frequent fatal complication. It is proportional not to circulating parasitemia but total parasite mass (sequestered) in the organs. Thus, immune responses that clear parasites in org...

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發表在:mBio
Main Authors: Safeukui, Innocent, Gomez, Noé D., Adelani, Aanuoluwa A., Burte, Florence, Afolabi, Nathaniel K., Akondy, Rama, Velazquez, Peter, Holder, Anthony, Tewari, Rita, Buffet, Pierre, Brown, Biobele J., Shokunbi, Wuraola A., Olaleye, David, Sodeinde, Olugbemiro, Kazura, James, Ahmed, Rafi, Mohandas, Narla, Fernandez-Reyes, Delmiro, Haldar, Kasturi
格式: Artigo
語言:Inglês
出版: American Society of Microbiology 2015
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324318/
https://ncbi.nlm.nih.gov/pubmed/25604792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02493-14
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