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α-2,3-Sialyltransferase Expression Level Impacts the Kinetics of Lipooligosaccharide Sialylation, Complement Resistance, and the Ability of Neisseria gonorrhoeae to Colonize the Murine Genital Tract

Neisseria meningitidis and Neisseria gonorrhoeae modify the terminal lacto-N-neotetraose moiety of their lipooligosaccharide (LOS) with sialic acid. N. gonorrhoeae LOS sialylation blocks killing by complement, which is mediated at least in part by enhanced binding of the complement inhibitor factor...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:mBio
Päätekijät: Lewis, Lisa A., Gulati, Sunita, Burrowes, Elizabeth, Zheng, Bo, Ram, Sanjay, Rice, Peter A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Microbiology 2015
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324315/
https://ncbi.nlm.nih.gov/pubmed/25650401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02465-14
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