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Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors.

We have identified the nucleotide sequence of the cDNA encoding the human counterpart of the mouse gene Plk (polo-like kinase). The sequence of the human gene, PLK, predicts a serine/threonine kinase of 603 aa. Expression of PLK mRNA appeared to be strongly correlated with the mitotic activity of ce...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Holtrich, U, Wolf, G, Bräuninger, A, Karn, T, Böhme, B, Rübsamen-Waigmann, H, Strebhardt, K
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43238/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8127874/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.5.1736
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