IRF5 deficiency ameliorates lupus but promotes atherosclerosis and metabolic dysfunction in a mouse model of lupus-associated atherosclerosis

Premature atherosclerosis is a severe complication of lupus and other systemic autoimmune disorders. Gain-of-function polymorphisms in interferon regulatory factor 5 (IRF5) are associated with an increased risk of developing lupus and IRF5 deficiency in lupus mouse models ameliorates disease. Howeve...

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Publicat a:J Immunol
Autors principals: Watkins, Amanda A., Yasuda, Kei, Wilson, Gabriella E., Aprahamian, Tamar, Xie, Yao, Maganto-Garcia, Elena, Shukla, Prachi, Oberlander, Lillian, Laskow, Bari, Menn-Josephy, Hanni, Wu, Yuanyuan, Duffau, Pierre, Fried, Susan K., Lichtman, Andrew H., Bonegio, Ramon G., Rifkin, Ian R.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323680/
https://ncbi.nlm.nih.gov/pubmed/25595782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402807
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