Recombinant Influenza Virus Expressing a Fusion Protein Neutralizing Epitope of Respiratory Syncytial Virus (RSV) Confers Protection without Vaccine-Enhanced RSV Disease

Respiratory syncytial virus (RSV) is the leading cause of viral bronchiolitis in both children and the elderly. There is no vaccine available for the prevention of RSV infection. Here, we generated recombinant influenza virus (PR8/RSV.HA-F) expressing an RSV F(243–294) neutralizing epitope in the he...

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Veröffentlicht in:Antiviral Res
Hauptverfasser: Lee, Yu-Na, Hwang, Hye Suk, Kim, Min-Chul, Lee, Young-Tae, Lee, Jong Seok, Moore, Martin L., Kang, Sang-Moo
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323669/
https://ncbi.nlm.nih.gov/pubmed/25513755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2014.12.009
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