Defective selection of thymic regulatory T cells accompanies autoimmunity and pulmonary infiltrates in Tcra-deficient mice double transgenic for human La/SS-B and human La-specific T cell receptor()

A human La/SS-B (hLa)-specific TCR/hLa neo-self antigen double transgenic mouse model was developed and used to investigate cellular tolerance and autoimmunity to the ubiquitous RNA-binding La antigen often targeted in systemic lupus erythematosus and Sjögren's syndrome. Extensive thymic clonal...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Yaciuk, Jane C., Pan, Yujun, Schwarz, Karen, Pan, Zi-jian, Maier-Moore, Jacen S., Kosanke, Stanley D., Lawrence, Christina, Farris, A. Darise
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323622/
https://ncbi.nlm.nih.gov/pubmed/25582858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400319
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