The selective tRNA aminoacylation mechanism based on a single G•U pair

Ligation of tRNAs with their cognate amino acids, by aminoacyl-tRNA synthetases, establishes the genetic code. Throughout evolution, tRNA(Ala) selection by alanyl-tRNA synthetase (AlaRS) has depended predominantly on a single wobble base pair in the acceptor stem, G3•U70, mainly on the k(cat) level....

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Pubblicato in:Nature
Autori principali: Naganuma, Masahiro, Sekine, Shun-ichi, Chong, Yeeting Esther, Guo, Min, Yang, Xiang-Lei, Gamper, Howard, Hou, Ya-Ming, Schimmel, Paul, Yokoyama, Shigeyuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323281/
https://ncbi.nlm.nih.gov/pubmed/24919148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13440
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