Cys-scanning Disulfide crosslinking and Bayesian modeling probe the transmembrane signaling mechanism of the histidine kinase, PhoQ

Bacteria transduce signals across the membrane using two-component systems (TCSs), consisting of a membrane-spanning sensor histidine kinase and a cytoplasmic response regulator. In Gram negative bacteria, the PhoPQ TCS senses cations and antimicrobial peptides, yet little is known about the structu...

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Detalhes bibliográficos
Publicado no:Structure
Main Authors: Molnar, Kathleen S, Bonomi, Massimiliano, Pellarin, Riccardo, Clinthorne, Graham D, Gonzalez, Gabriel, Goldberg, Shalom D, Goulian, Mark, Sali, Andrej, DeGrado, William F
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4322757/
https://ncbi.nlm.nih.gov/pubmed/25087511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.04.019
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