IER3 is a crucial mediator of TAp73β-induced apoptosis in cervical cancer and confers etoposide sensitivity

Infection with high-risk human papillomaviruses (HPVs) causes cervical cancer. E6 oncoprotein, an HPV gene product, inactivates the major gatekeeper p53. In contrast, its isoform, TAp73β, has become increasingly important, as it is resistant to E6. However, the intracellular signaling mechanisms tha...

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Vydáno v:Sci Rep
Hlavní autoři: Jin, Hanyong, Suh, Dae-Shik, Kim, Tae-Hyoung, Yeom, Ji-Hyun, Lee, Kangseok, Bae, Jeehyeon
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4322356/
https://ncbi.nlm.nih.gov/pubmed/25666857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08367
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