ICOS maintains the T follicular helper cell phenotype by down-regulating Krüppel-like factor 2

The co-stimulators ICOS (inducible T cell co-stimulator) and CD28 are both important for T follicular helper (TFH) cells, yet their individual contributions are unclear. Here, we show that each molecule plays an exclusive role at different stages of TFH cell development. While CD28 regulated early e...

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Detalhes bibliográficos
Publicado no:J Exp Med
Principais autores: Weber, Jan P., Fuhrmann, Franziska, Feist, Randi K., Lahmann, Annette, Al Baz, Maysun S., Gentz, Lea-Jean, Vu Van, Dana, Mages, Hans W., Haftmann, Claudia, Riedel, René, Grün, Joachim R., Schuh, Wolfgang, Kroczek, Richard A., Radbruch, Andreas, Mashreghi, Mir-Farzin, Hutloff, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4322049/
https://ncbi.nlm.nih.gov/pubmed/25646266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141432
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