LRP5 Regulates Human Body Fat Distribution by Modulating Adipose Progenitor Biology in a Dose- and Depot-Specific Fashion

Common variants in WNT pathway genes have been associated with bone mass and fat distribution, the latter predicting diabetes and cardiovascular disease risk. Rare mutations in the WNT co-receptors LRP5 and LRP6 are similarly associated with bone and cardiometabolic disorders. We investigated the ro...

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Veröffentlicht in:Cell Metab
Hauptverfasser: Loh, Nellie Y., Neville, Matt J., Marinou, Kyriakoula, Hardcastle, Sarah A., Fielding, Barbara A., Duncan, Emma L., McCarthy, Mark I., Tobias, Jonathan H., Gregson, Celia L., Karpe, Fredrik, Christodoulides, Constantinos
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321886/
https://ncbi.nlm.nih.gov/pubmed/25651180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.01.009
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