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Antibody repertoire diversification through VH gene replacement in mice cloned from an IgA plasma cell
In mammals, VDJ recombination is responsible for the establishment of a highly diversified preimmune antibody repertoire. Acquisition of a functional Ig heavy (H) chain variable (V) gene rearrangement is thought to prevent further recombination at the IgH locus. Here, we describe V(H)Q52(NT); Vκgr32...
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| Опубликовано в: : | Proc Natl Acad Sci U S A |
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| Главные авторы: | , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4321288/ https://ncbi.nlm.nih.gov/pubmed/25609671 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417988112 |
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