Antibody repertoire diversification through VH gene replacement in mice cloned from an IgA plasma cell

In mammals, VDJ recombination is responsible for the establishment of a highly diversified preimmune antibody repertoire. Acquisition of a functional Ig heavy (H) chain variable (V) gene rearrangement is thought to prevent further recombination at the IgH locus. Here, we describe V(H)Q52(NT); Vκgr32...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Kumar, Rashmi, Bach, Martina P., Mainoldi, Federica, Maruya, Mikako, Kishigami, Satoshi, Jumaa, Hassan, Wakayama, Teruhiko, Kanagawa, Osami, Fagarasan, Sidonia, Casola, Stefano
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321288/
https://ncbi.nlm.nih.gov/pubmed/25609671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417988112
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