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A preliminary exploration on DNA methylation of transgene across generations in transgenic rats

Epigenetic heritability is an important issue in the field of genetics and also in the development of many human diseases. In this study, we created a transgenic rat model and investigated the transgenerational methylation patterns in these animals. The transgene DNA fragment was unmethylated before...

詳細記述

保存先:
書誌詳細
出版年:Sci Rep
主要な著者: Li, Qiling, Xu, Wei, Cui, Ye, Ma, Li, Richards, Jendai, Li, Wenzhi, Ma, Yamin, Fu, Guoxing, Bythwood, Tameka, Wang, Yueling, Li, Xu, Song, Qing
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321119/
https://ncbi.nlm.nih.gov/pubmed/25659774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08292
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