Attachment of cell-binding ligands to arginine-rich cell penetrating peptides enables cytosolic translocation of complexed siRNA

Cell penetrating peptides (CPPs) like nona-arginine (9R) poorly translocate siRNA into cells. Our studies demonstrate that attaching 9R to ligands that bind cell-surface receptors quantitatively increases siRNA uptake and importantly, allows functional delivery of complexed siRNA. The mechanism invo...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Chem Biol
Hlavní autoři: Zeller, Skye, Choi, Changseon, Uchil, Pradeep D., Ban, Hongseok, Siefert, Alyssa, Fahmy, Tarek M., Mothes, Walther, Lee, Sang Kyung, Kumar, Priti
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4320807/
https://ncbi.nlm.nih.gov/pubmed/25544044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.11.009
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky