PKCζ and PKMζ are overexpressed in TCF3-rearranged paediatric acute lymphoblastic leukaemia and are associated with increased thiopurine sensitivity

Both tumour suppressor and oncogenic functions have been ascribed to the atypical zeta isoform of protein kinase C (PKCζ), whereas its constitutively active form PKMζ is almost exclusively expressed in the brain where it has a role in long-term memory. Using primers unique for either isoform, we fou...

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Publicat a:Leukemia
Autors principals: Hartsink-Segers, S A, Beaudoin, J J, Luijendijk, M W J, Exalto, C, Pieters, R, Den Boer, M L
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4320296/
https://ncbi.nlm.nih.gov/pubmed/24990612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2014.210
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