Chronic Lung Injury by Constitutive Expression of Activation-Induced Cytidine Deaminase Leads to Focal Mucous Cell Metaplasia and Cancer

Activation-induced cytidine deaminase (AID) is an enzyme required for antibody diversification, and it causes DNA mutations and strand breaks. Constitutive AID expression in mice invariably caused lung lesions morphologically similar to human atypical adenomatous hyperplasia (AAH), which can be a pr...

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Publicado en:PLoS One
Main Authors: Kitamura, Jiro, Uemura, Munehiro, Kurozumi, Mafumi, Sonobe, Makoto, Manabe, Toshiaki, Hiai, Hiroshi, Date, Hiroshi, Kinoshita, Kazuo
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4320068/
https://ncbi.nlm.nih.gov/pubmed/25659078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117986
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