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Role of high-molecular-weight kininogen in surface-binding and activation of coagulation Factor XI and prekallikrein.

In the contact phase of activation of the kinin-forming, intrinsic clotting, and fibrinolytic systems, high-molecular-weight kininogen acts as a cofactor for the activation of Factor XI, prekallikrein, and Hageman factor. One mechanism by which high-molecular-weight kininogen acts as a cofactor has...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Wiggins, R C, Bouma, B N, Cochrane, C G, Griffin, J H
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1977
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC432002/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/270705/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.74.10.4636
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