5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation

In mammals, cytosine methylation (5mC) is widely distributed throughout the genome, but is notably depleted from active promoters and enhancers. While the role of DNA methylation in promoter silencing has been well documented, the function of this epigenetic mark at enhancers remains unclear. Recent...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Hon, Gary C., Song, Chun-Xiao, Du, Tingting, Jin, Fulai, Selvaraj, Siddarth, Lee, Ah Young, Yen, Chia-an, Ye, Zhen, Mao, Shi-Qing, Wang, Bang-An, Kuan, Samantha, Edsall, Lee E., Zhao, Boxuan Simen, Xu, Guo-Liang, He, Chuan, Ren, Bing
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319980/
https://ncbi.nlm.nih.gov/pubmed/25263596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.08.026
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