5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation

In mammals, cytosine methylation (5mC) is widely distributed throughout the genome, but is notably depleted from active promoters and enhancers. While the role of DNA methylation in promoter silencing has been well documented, the function of this epigenetic mark at enhancers remains unclear. Recent...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell
Prif Awduron: Hon, Gary C., Song, Chun-Xiao, Du, Tingting, Jin, Fulai, Selvaraj, Siddarth, Lee, Ah Young, Yen, Chia-an, Ye, Zhen, Mao, Shi-Qing, Wang, Bang-An, Kuan, Samantha, Edsall, Lee E., Zhao, Boxuan Simen, Xu, Guo-Liang, He, Chuan, Ren, Bing
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319980/
https://ncbi.nlm.nih.gov/pubmed/25263596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.08.026
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