5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation

In mammals, cytosine methylation (5mC) is widely distributed throughout the genome, but is notably depleted from active promoters and enhancers. While the role of DNA methylation in promoter silencing has been well documented, the function of this epigenetic mark at enhancers remains unclear. Recent...

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Detaylı Bibliyografya
Yayımlandı:Mol Cell
Asıl Yazarlar: Hon, Gary C., Song, Chun-Xiao, Du, Tingting, Jin, Fulai, Selvaraj, Siddarth, Lee, Ah Young, Yen, Chia-an, Ye, Zhen, Mao, Shi-Qing, Wang, Bang-An, Kuan, Samantha, Edsall, Lee E., Zhao, Boxuan Simen, Xu, Guo-Liang, He, Chuan, Ren, Bing
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319980/
https://ncbi.nlm.nih.gov/pubmed/25263596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.08.026
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