5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation

In mammals, cytosine methylation (5mC) is widely distributed throughout the genome, but is notably depleted from active promoters and enhancers. While the role of DNA methylation in promoter silencing has been well documented, the function of this epigenetic mark at enhancers remains unclear. Recent...

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Publicat a:Mol Cell
Autors principals: Hon, Gary C., Song, Chun-Xiao, Du, Tingting, Jin, Fulai, Selvaraj, Siddarth, Lee, Ah Young, Yen, Chia-an, Ye, Zhen, Mao, Shi-Qing, Wang, Bang-An, Kuan, Samantha, Edsall, Lee E., Zhao, Boxuan Simen, Xu, Guo-Liang, He, Chuan, Ren, Bing
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319980/
https://ncbi.nlm.nih.gov/pubmed/25263596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.08.026
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