5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation

In mammals, cytosine methylation (5mC) is widely distributed throughout the genome, but is notably depleted from active promoters and enhancers. While the role of DNA methylation in promoter silencing has been well documented, the function of this epigenetic mark at enhancers remains unclear. Recent...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Mol Cell
Κύριοι συγγραφείς: Hon, Gary C., Song, Chun-Xiao, Du, Tingting, Jin, Fulai, Selvaraj, Siddarth, Lee, Ah Young, Yen, Chia-an, Ye, Zhen, Mao, Shi-Qing, Wang, Bang-An, Kuan, Samantha, Edsall, Lee E., Zhao, Boxuan Simen, Xu, Guo-Liang, He, Chuan, Ren, Bing
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2014
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319980/
https://ncbi.nlm.nih.gov/pubmed/25263596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.08.026
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