β-Hydroxy-β-Methylbutyrate (HMB) Normalizes Dexamethasone-Induced Autophagy-Lysosomal Pathway in Skeletal Muscle

Dexamethasone-induced muscle atrophy is due to an increase in protein breakdown and a decrease in protein synthesis, associated with an over-stimulation of the autophagy-lysosomal pathway. These effects are mediated by alterations in IGF-1 and PI3K/Akt signaling. In this study, we have investigated...

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Vydáno v:PLoS One
Hlavní autoři: Girón, María D., Vílchez, Jose D., Shreeram, Sathyavageeswaran, Salto, Rafael, Manzano, Manuel, Cabrera, Elena, Campos, Nefertiti, Edens, Neile K., Rueda, Ricardo, López-Pedrosa, Jose M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319954/
https://ncbi.nlm.nih.gov/pubmed/25658432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117520
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