Urate Crystal Induced Inflammation and Joint Pain Are Reduced in Transient Receptor Potential Ankyrin 1 Deficient Mice – Potential Role for Transient Receptor Potential Ankyrin 1 in Gout

INTRODUCTION: In gout, monosodium urate (MSU) crystals deposit intra-articularly and cause painful arthritis. In the present study we tested the hypothesis that Transient Receptor Poten-tial Ankyrin 1 (TRPA1), an ion channel mediating nociceptive signals and neurogenic in-flammation, is involved in...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Moilanen, Lauri J., Hämäläinen, Mari, Lehtimäki, Lauri, Nieminen, Riina M., Moilanen, Eeva
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319920/
https://ncbi.nlm.nih.gov/pubmed/25658427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117770
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