Neurodegeneration and Unfolded-Protein Response in Mice Expressing a Membrane-Tethered Flexible Tail of PrP

The cellular prion protein (PrP(C)) consists of a flexible N-terminal tail (FT, aa 23–128) hinged to a membrane-anchored globular domain (GD, aa 129–231). Ligation of the GD with antibodies induces rapid neurodegeneration, which is prevented by deletion or functional inactivation of the FT. Therefor...

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Pubblicato in:PLoS One
Autori principali: Dametto, Paolo, Lakkaraju, Asvin K. K., Bridel, Claire, Villiger, Lukas, O’Connor, Tracy, Herrmann, Uli S., Pelczar, Pawel, Rülicke, Thomas, McHugh, Donal, Adili, Arlind, Aguzzi, Adriano
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319788/
https://ncbi.nlm.nih.gov/pubmed/25658480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117412
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