Vector design influences hepatic genotoxicity after adeno-associated virus gene therapy

The use of adeno-associated virus (AAV) as a gene therapy vector has been approved recently for clinical use and has demonstrated efficacy in a growing number of clinical trials. However, the safety of AAV as a vector has been challenged by a single study that documented hepatocellular carcinoma (HC...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Chandler, Randy J., LaFave, Matthew C., Varshney, Gaurav K., Trivedi, Niraj S., Carrillo-Carrasco, Nuria, Senac, Julien S., Wu, Weiwei, Hoffmann, Victoria, Elkahloun, Abdel G., Burgess, Shawn M., Venditti, Charles P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319425/
https://ncbi.nlm.nih.gov/pubmed/25607839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI79213
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