NOTCH pathway inactivation promotes bladder cancer progression

NOTCH signaling suppresses tumor growth and proliferation in several types of stratified epithelia. Here, we show that missense mutations in NOTCH1 and NOTCH2 found in human bladder cancers result in loss of function. In murine models, genetic ablation of the NOTCH pathway accelerated bladder tumori...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Maraver, Antonio, Fernandez-Marcos, Pablo J., Cash, Timothy P., Mendez-Pertuz, Marinela, Dueñas, Marta, Maietta, Paolo, Martinelli, Paola, Muñoz-Martin, Maribel, Martínez-Fernández, Mónica, Cañamero, Marta, Roncador, Giovanna, Martinez-Torrecuadrada, Jorge L., Grivas, Dimitrios, de la Pompa, Jose Luis, Valencia, Alfonso, Paramio, Jesús M., Real, Francisco X., Serrano, Manuel
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319408/
https://ncbi.nlm.nih.gov/pubmed/25574842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI78185
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