NOTCH pathway inactivation promotes bladder cancer progression

NOTCH signaling suppresses tumor growth and proliferation in several types of stratified epithelia. Here, we show that missense mutations in NOTCH1 and NOTCH2 found in human bladder cancers result in loss of function. In murine models, genetic ablation of the NOTCH pathway accelerated bladder tumori...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Clin Invest
Egile Nagusiak: Maraver, Antonio, Fernandez-Marcos, Pablo J., Cash, Timothy P., Mendez-Pertuz, Marinela, Dueñas, Marta, Maietta, Paolo, Martinelli, Paola, Muñoz-Martin, Maribel, Martínez-Fernández, Mónica, Cañamero, Marta, Roncador, Giovanna, Martinez-Torrecuadrada, Jorge L., Grivas, Dimitrios, de la Pompa, Jose Luis, Valencia, Alfonso, Paramio, Jesús M., Real, Francisco X., Serrano, Manuel
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2015
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319408/
https://ncbi.nlm.nih.gov/pubmed/25574842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI78185
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