A common genetic variation of melanoma inhibitory activity-2 labels a subtype of pancreatic adenocarcinoma with high endoplasmic reticulum stress levels

HNF1 homeobox A (HNF1A)-mediated gene expression constitutes an essential component of the secretory pathway in the exocrine pancreas. Melanoma inhibitory activity 2 (MIA2), a protein facilitating protein secretion, is an HNF1A target. Protein secretion is precisely coordinated by the endoplasmic re...

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Опубликовано в: :Sci Rep
Главные авторы: Kong, Bo, Wu, Weiwei, Valkovska, Nataliya, Jäger, Carsten, Hong, Xin, Nitsche, Ulrich, Friess, Helmut, Esposito, Irene, Erkan, Mert, Kleeff, Jörg, Michalski, Christoph W.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319175/
https://ncbi.nlm.nih.gov/pubmed/25657029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08109
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