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The Bordetella Adenylate Cyclase Repeat-in-Toxin (RTX) Domain Is Immunodominant and Elicits Neutralizing Antibodies
The adenylate cyclase toxin (ACT) is a multifunctional virulence factor secreted by Bordetella species. Upon interaction of its C-terminal hemolysin moiety with the cell surface receptor α(M)β(2) integrin, the N-terminal cyclase domain translocates into the host cell cytosol where it rapidly generat...
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| 發表在: | J Biol Chem |
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| Main Authors: | , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4319024/ https://ncbi.nlm.nih.gov/pubmed/25505186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.585281 |
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