Design, creation, and characterization of a stable, monomeric triosephosphate isomerase.

Protein engineering on trypanosomal triosephosphate isomerase (TIM) converted this oligomeric enzyme into a stable, monomeric protein that is enzymatically active. Wild-type TIM consists of two identical subunits that form a very tight dimer involving interactions of 32 residues of each subunit. By...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Borchert, T V, Abagyan, R, Jaenicke, R, Wierenga, R K
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1994
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43190/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8108439/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.4.1515
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