Farnesoid X Receptor Antagonizes JNK Signaling Pathway in Liver Carcinogenesis by Activating SOD3

The farnesoid X receptor (FXR) is a key metabolic and homeostatic regulator in the liver. In the present work, we identify a novel role of FXR in antagonizing c-Jun N-terminal kinase (JNK) signaling pathway in liver carcinogenesis by activating superoxide dismutase 3 (SOD3) transcription. Compared w...

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Detalhes bibliográficos
Publicado no:Mol Endocrinol
Main Authors: Wang, Yan-Dong, Chen, Wei-Dong, Li, Cunbao, Guo, Cong, Li, Yanyan, Qi, Hui, Shen, Hailing, Kong, Jing, Long, Xuecheng, Yuan, Frank, Wang, Xichun, Huang, Wendong
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4318883/
https://ncbi.nlm.nih.gov/pubmed/25496033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2014-1225
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