An Unusual Peroxo Intermediate of the Arylamine Oxygenase of the Chloramphenicol Biosynthetic Pathway

Streptomyces venezuelae CmlI catalyzes the 6-electron oxygenation of the arylamine precursor of chloramphenicol in a nonribosomal peptide synthetase (NRPS)-based pathway to yield the nitroaryl group of the antibiotic. Optical, EPR, and Mössbauer studies show that the enzyme contains a nonheme dinucl...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:J Am Chem Soc
Autors principals: Makris, Thomas M., Vu, Van V., Meier, Katlyn K., Komor, Anna J., Rivard, Brent S., Münck, Eckard, Que, Lawrence, Lipscomb, John D.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4318726/
https://ncbi.nlm.nih.gov/pubmed/25564306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja511649n
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars