Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine

A guanine derivative with an acyclic side chain, 2-hydroxyethoxymethyl, at position 9 has potent antiviral activity [dose for 50% inhibition (ED(50)) = 0.1 μM] against herpes simplex virus type 1. This acyclic nucleoside analog, termed acycloguanosine, is converted to a monophosphate by a virus-spec...

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Autores principales: Elion, Gertrude B., Furman, Phillip A., Fyfe, James A., Miranda, Paulo de, Beauchamp, Lilia, Schaeffer, Howard J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 1977
Materias:
Biological Sciences: Medical Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC431864/
https://ncbi.nlm.nih.gov/pubmed/202961
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