Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine

A guanine derivative with an acyclic side chain, 2-hydroxyethoxymethyl, at position 9 has potent antiviral activity [dose for 50% inhibition (ED(50)) = 0.1 μM] against herpes simplex virus type 1. This acyclic nucleoside analog, termed acycloguanosine, is converted to a monophosphate by a virus-spec...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Elion, Gertrude B., Furman, Phillip A., Fyfe, James A., Miranda, Paulo de, Beauchamp, Lilia, Schaeffer, Howard J.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1977
Subjects:
Biological Sciences: Medical Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC431864/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/202961/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.74.12.5716
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