Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate.

The effect of the nucleoside analog 9-(2-hydroxyethoxymethyl)guanine (acycloguanosine) on herpes simplex virus type 1 DNA synthesis was examined. Acycloguanosine inhibited herpesvirus DNA synthesis in virus-infected cells. The synthesis of host cell DNA was only partially inhibited in actively growi...

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Publié dans:	J Virol
Auteurs principaux:	Furman, P A, St Clair, M H, Fyfe, J A, Rideout, J L, Keller, P M, Elion, G B
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1979
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC353528/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/232189/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.32.1.72-77.1979
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