Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate.

The effect of the nucleoside analog 9-(2-hydroxyethoxymethyl)guanine (acycloguanosine) on herpes simplex virus type 1 DNA synthesis was examined. Acycloguanosine inhibited herpesvirus DNA synthesis in virus-infected cells. The synthesis of host cell DNA was only partially inhibited in actively growi...

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Autori principali: Furman, P A, St Clair, M H, Fyfe, J A, Rideout, J L, Keller, P M, Elion, G B
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1979
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC353528/
https://ncbi.nlm.nih.gov/pubmed/232189
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