Unusual pulmonary vasodilator activity of 13,14-dehydroprostacyclin methyl ester: comparison with endoperoxides and other prostanoids.

Microsomes from stomach fundus and blood vessels transform the endoperoxide, PGH2, into a newly discovered unstable substance, PGI2, that relaxes arterial strips and inhibits platelet aggregation. 13,14-Dehydro-PGI2 methyl ester, a newly synthesized, stable PGI2 analog, was found to have potent vaso...

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Detalhes bibliográficos
Main Authors: Hyman, A L, Chapnick, B M, Kadowitz, P J, Lands, W E, Crawford, C G, Fried, J, Barton, J
Formato: Artigo
Idioma:Inglês
Publicado em: 1977
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC431863/
https://ncbi.nlm.nih.gov/pubmed/414226
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