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Evidence for a long-range conformational change induced by antigen binding to IgM antibody.

The effects of antigen binding on IgM antibody conformation were investigated by measuring the immunological reactivity of the Fc-bound J polypeptide. For such measurements anti-azophenyl-beta-D-lactoside and anti-azobenzenearsonate IgM antibodies were examined in a J chain radioimmunoassay before a...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Principais autores: Brown, J C, Koshland, M E
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 1977
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC431857/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/74832/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.74.12.5682
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