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Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: Possible role of nucleoside kinase(s)

Inherited deficiencies of the enzymes adenosine deaminase (adenosine aminohydrolase; EC 3.5.4.4) and purine nucleoside phosphorylase (purine-nucleoside:orthophosphate ribosyltransferase; EC 2.4.2.1) preferentially interfere with lymphocyte development while sparing most other organ systems. Previous...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Carson, Dennis A., Kaye, Jonathan, Seegmiller, J. E.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1977
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC431856/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/202960/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.74.12.5677
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