5-Lipoxygenase and cysteinyl leukotriene receptor 1 regulate epidermal growth factor-induced cell migration through Tiam1 upregulation and Rac1 activation

Cell migration is an essential step for tumor metastasis. The small GTPase Rac1 plays an important role in cell migration. Previously, we reported that epidermal growth factor (EGF) induced two waves of Rac1 activation; namely, at 5 min and 12 h after stimulation. A second wave of EGF-induced Rac1 a...

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Bibliographic Details
Published in:Cancer Sci
Main Authors: Magi, Shigeyuki, Takemoto, Yasushi, Kobayashi, Hiroki, Kasamatsu, Masato, Akita, Takahiro, Tanaka, Ayako, Takano, Kei, Tashiro, Etsu, Igarashi, Yasuhiro, Imoto, Masaya
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2014
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317946/
https://ncbi.nlm.nih.gov/pubmed/24350867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12340
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