5-Lipoxygenase and cysteinyl leukotriene receptor 1 regulate epidermal growth factor-induced cell migration through Tiam1 upregulation and Rac1 activation

Cell migration is an essential step for tumor metastasis. The small GTPase Rac1 plays an important role in cell migration. Previously, we reported that epidermal growth factor (EGF) induced two waves of Rac1 activation; namely, at 5 min and 12 h after stimulation. A second wave of EGF-induced Rac1 a...

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Bibliographische Detailangaben
Veröffentlicht in:Cancer Sci
Hauptverfasser: Magi, Shigeyuki, Takemoto, Yasushi, Kobayashi, Hiroki, Kasamatsu, Masato, Akita, Takahiro, Tanaka, Ayako, Takano, Kei, Tashiro, Etsu, Igarashi, Yasuhiro, Imoto, Masaya
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2014
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317946/
https://ncbi.nlm.nih.gov/pubmed/24350867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12340
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