Intracranial Biodegradable Silica-Based Nimodipine Drug Release Implant for Treating Vasospasm in Subarachnoid Hemorrhage in an Experimental Healthy Pig and Dog Model

Nimodipine is a widely used medication for treating delayed cerebral ischemia (DCI) after subarachnoid hemorrhage. When administrated orally or intravenously, systemic hypotension is an undesirable side effect. Intracranial subarachnoid delivery of nimodipine during aneurysm clipping may be more eff...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Koskimäki, Janne, Tarkia, Miikka, Ahtola-Sätilä, Tuula, Saloranta, Lasse, Simola, Outi, Forsback, Ari-Pekka, Laakso, Aki, Frantzén, Janek
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317635/
https://ncbi.nlm.nih.gov/pubmed/25685803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/715752
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