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Development of sequence-specific antimicrobials based on programmable CRISPR-Cas nucleases
Antibiotics target conserved bacterial cellular pathways or growth functions and therefore cannot selectively kill specific members of a complex microbial population. Here, we develop programmable, sequence-specific antimicrobials using the RNA-guided nuclease Cas9(1, 2) delivered by a bacteriophage...
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| Publicado no: | Nat Biotechnol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4317352/ https://ncbi.nlm.nih.gov/pubmed/25282355 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3043 |
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