Development of sequence-specific antimicrobials based on programmable CRISPR-Cas nucleases

Antibiotics target conserved bacterial cellular pathways or growth functions and therefore cannot selectively kill specific members of a complex microbial population. Here, we develop programmable, sequence-specific antimicrobials using the RNA-guided nuclease Cas9(1, 2) delivered by a bacteriophage...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Nat Biotechnol
Main Authors: Bikard, David, Euler, Chad, Jiang, Wenyan, Nussenzweig, Philip M., Goldberg, Gregory W., Duportet, Xavier, Fischetti, Vincent A., Marraffini, Luciano A.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317352/
https://ncbi.nlm.nih.gov/pubmed/25282355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3043
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares