Prediction of clinical pharmacokinetics of AMG 181, a human anti-α(4)β(7) monoclonal antibody for treating inflammatory bowel diseases

The purpose of this study was to predict a safe starting dose of AMG 181, a human anti-α(4)β(7) antibody for treating inflammatory bowel diseases, based on cynomolgus monkey pharmacokinetic (PK) and pharmacodynamic (PD) data. A two-compartment model with parallel linear and target-mediated drug disp...

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Foilsithe in:Pharmacol Res Perspect
Main Authors: Li, Hong, Köck, Kathleen, Wisler, John A, Rees, William A, Prince, Peter J, Reynhardt, Kai O, Hsu, Hailing, Yu, Zhigang, Borie, Dominic C, Salinger, David H, Pan, Wei-Jian
Formáid: Artigo
Teanga:Inglês
Foilsithe: BlackWell Publishing Ltd 2015
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Original Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317229/
https://ncbi.nlm.nih.gov/pubmed/25692016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.98
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