Clinical pharmacology of AMG 181, a gut-specific human anti-α(4)β(7) monoclonal antibody, for treating inflammatory bowel diseases

AIMS: AMG 181 pharmacokinetics/pharmacodynamics (PK/PD), safety, tolerability and effects after single subcutaneous (s.c.) or intravenous (i.v.) administration were evaluated in a randomized, double-blind, placebo-controlled study. METHODS: Healthy male subjects (n= 68) received a single dose of AMG...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Pan, Wei-Jian, Köck, Kathleen, Rees, William A, Sullivan, Barbara A, Evangelista, Christine M, Yen, Mark, Andrews, Jane M, Radford-Smith, Graham L, Prince, Peter J, Reynhardt, Kaz O, Doherty, David R, Patel, Sonal K, Krill, Christine D, Zhou, Kefei, Shen, Jing, Smith, Lynn E, Gow, Jason M, Lee, Jonathan, Treacy, Anthony M, Yu, Zhigang, Platt, Virginia M, Borie, Dominic C
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Clinical Trials
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256621/
https://ncbi.nlm.nih.gov/pubmed/24803302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12418
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