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Functional Characterization of Ca(V)α2δ Mutations Associated with Sudden Cardiac Death
L-type Ca(2+) channels play a critical role in cardiac rhythmicity. These ion channels are oligomeric complexes formed by the pore-forming Ca(V)α1 with the auxiliary Ca(V)β and Ca(V)α2δ subunits. Ca(V)α2δ increases the peak current density and improves the voltage-dependent activation gating of Ca(V...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4317020/ https://ncbi.nlm.nih.gov/pubmed/25527503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.597930 |
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