Structural and Inhibitory Effects of Hinge Loop Mutagenesis in Serpin-2 from the Malaria Vector Anopheles gambiae

Serpin-2 (SRPN2) is a key negative regulator of the melanization response in the malaria vector Anopheles gambiae. SRPN2 irreversibly inhibits clip domain serine proteinase 9 (CLIPB9), which functions in a serine proteinase cascade culminating in the activation of prophenoloxidase and melanization....

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Udgivet i:J Biol Chem
Main Authors: Zhang, Xin, Meekins, David A., An, Chunju, Zolkiewski, Michal, Battaile, Kevin P., Kanost, Michael R., Lovell, Scott, Michel, Kristin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Enzymology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317006/
https://ncbi.nlm.nih.gov/pubmed/25525260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.625665
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