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The β-Lactamase Gene Regulator AmpR Is a Tetramer That Recognizes and Binds the d-Ala-d-Ala Motif of Its Repressor UDP-N-acetylmuramic Acid (MurNAc)-pentapeptide

Inducible expression of chromosomal AmpC β-lactamase is a major cause of β-lactam antibiotic resistance in the Gram-negative bacteria Pseudomonas aeruginosa and Enterobacteriaceae. AmpC expression is induced by the LysR-type transcriptional regulator (LTTR) AmpR, which activates ampC expression in r...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Vadlamani, Grishma, Thomas, Misty D., Patel, Trushar R., Donald, Lynda J., Reeve, Thomas M., Stetefeld, Jörg, Standing, Kenneth G., Vocadlo, David J., Mark, Brian L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4316999/
https://ncbi.nlm.nih.gov/pubmed/25480792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.618199
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