Variation in pre-PCR processing of FFPE samples leads to discrepancies in BRAF and EGFR mutation detection: a diagnostic RING trial

AIMS: Mutation detection accuracy has been described extensively; however, it is surprising that pre-PCR processing of formalin-fixed paraffin-embedded (FFPE) samples has not been systematically assessed in clinical context. We designed a RING trial to (i) investigate pre-PCR variability, (ii) corre...

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Veröffentlicht in:J Clin Pathol
Hauptverfasser: Kapp, Joshua R, Diss, Tim, Spicer, James, Gandy, Michael, Schrijver, Iris, Jennings, Lawrence J, Li, Marilyn M, Tsongalis, Gregory J, de Castro, David Gonzalez, Bridge, Julia A, Wallace, Andrew, Deignan, Joshua L, Hing, Sandra, Butler, Rachel, Verghese, Eldo, Latham, Gary J, Hamoudi, Rifat A
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2015
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4316935/
https://ncbi.nlm.nih.gov/pubmed/25430497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jclinpath-2014-202644
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