Interleukin-22 ameliorates liver fibrogenesis by attenuating hepatic stellate cell activation and downregulating the levels of inflammatory cytokines

AIM: To investigate the effect of interleukin (IL)-22 on hepatic fibrosis in mice and the possible mechanism involved. METHODS: Liver fibrosis was induced in male BALB/c mice by CCl(4). Recombinant IL-22 (rmIL-22) was administered intraperitoneally in CCl(4)-treated mice. Fibrosis was assessed by hi...

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Detalhes bibliográficos
Publicado no:World J Gastroenterol
Main Authors: Lu, Dong-Hong, Guo, Xiao-Yun, Qin, Shan-Yu, Luo, Wei, Huang, Xiao-Li, Chen, Mei, Wang, Jia-Xu, Ma, Shi-Jia, Yang, Xian-Wen, Jiang, Hai-Xing
Formato: Artigo
Idioma:Inglês
Publicado em: Baishideng Publishing Group Inc 2015
Assuntos:
Basic Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4316095/
https://ncbi.nlm.nih.gov/pubmed/25663772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v21.i5.1531
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